MAD2L2

Across TCGA patient cohorts, MAD2L2 mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAD2L2-associated genes across cancer lineages are RNU6-718P, MTRNR2L2, and RNA5SP414. Each is linked with MAD2L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAD2L2-to-partner and partner-to-MAD2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-718P grouped by MAD2L2-low versus MAD2L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAD2L2→partner) and Y-score (partner→MAD2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-718P →	+0.275	+4.555	<.001	.005	3	2
UCEC	MTRNR2L2 →	+0.705	+4.037	.005	.001	3	1
UCEC	RNA5SP414 →	+0.941	+3.670	<.001	.002	3	1
BLCA	MTND4P32 →	+0.072	+4.396	.006	.006	3	1
BLCA	MRPS21P5 →	+0.174	+4.497	<.001	.009	3	1
BLCA	RNU7-196P →	+0.485	+5.018	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

RNU6-718P by MAD2L2 expression — UCEC

Explore this box plot interactively →