MAD2L2

Across TCGA cell cohorts, MAD2L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,406 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAD2L2-associated GO terms across cancer lineages are Microtubule cytoskeleton organization involved in mitosis, Regulation of ubiquitin protein ligase activity, and Mitotic spindle organization. Each is linked with MAD2L2 in more than 18 cancer types. Because this analysis shows association rather than direction, both MAD2L2-to-partner and partner-to-MAD2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule cytoskeleton organization involved in mitosis grouped by MAD2L2-low versus MAD2L2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAD2L2→partner) and Y-score (partner→MAD2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Microtubule cytoskeleton organization involved in mitosis →	+0.091	+1.287	<.001	<.001	3	19
BREAST	Regulation of ubiquitin protein ligase activity →	+0.164	+1.373	<.001	<.001	3	19
BREAST	Mitotic spindle organization →	+0.084	+1.134	<.001	<.001	3	18
SKIN	Mitotic chromosome condensation →	+0.136	+0.818	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Regulation of metaphase/anaphase transition of cell cycle →	+0.117	+1.079	.001	.002	3	18
UPPER_AERODIGESTIVE_TRACT	Spindle organization →	+0.069	+0.850	.001	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,406 associations by consensus.

Microtubule cytoskeleton organization involved in mitosis by MAD2L2 expression — BREAST

Explore this box plot interactively →