MAD2L2

Across TCGA cell cohorts, MAD2L2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAD2L2-associated genes across cancer lineages are ETNPPL, PRAMEF9, and PRAMEF27. Each is linked with MAD2L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAD2L2-to-partner and partner-to-MAD2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETNPPL grouped by MAD2L2-low versus MAD2L2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAD2L2→partner) and Y-score (partner→MAD2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ETNPPL →	+0.222	+3.758	.002	.004	3	1
LARGE_INTESTINE	PRAMEF9 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF27 →	+0.003	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ETNPPL by MAD2L2 expression — LARGE_INTESTINE

Explore this box plot interactively →