MAD2L1

Across TCGA patient cohorts, MAD2L1 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAD2L1-associated genes across cancer lineages are pDC, Endothelial cells, and Erythrocytes. Each is linked with MAD2L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAD2L1-to-partner and partner-to-MAD2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, pDC grouped by MAD2L1-low versus MAD2L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAD2L1→partner) and Y-score (partner→MAD2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	pDC →	+0.081	+2.839	<.001	.034	3	2
UCEC	Endothelial cells →	-0.043	-3.416	.026	.005	3	1
UCEC	Erythrocytes →	+0.031	+2.879	.011	.033	3	1
UCEC	lymphatic Endothelial cells →	-0.024	-2.281	.040	.035	3	1
UCEC	mv Endothelial cells →	-0.025	-2.311	.034	.036	3	1
UCEC	Pericytes →	+0.039	+2.113	.003	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

pDC by MAD2L1 expression — UCEC

Explore this box plot interactively →