MAD2L1

Across TCGA cell cohorts, MAD2L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,800 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAD2L1-associated GO terms across cancer lineages are Protein localization to condensed chromosome, Regulation of chromosome condensation, and DNA-templated DNA replication. Each is linked with MAD2L1 in more than 19 cancer types. Because this analysis shows association rather than direction, both MAD2L1-to-partner and partner-to-MAD2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to condensed chromosome grouped by MAD2L1-low versus MAD2L1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAD2L1→partner) and Y-score (partner→MAD2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Protein localization to condensed chromosome →	+0.155	+1.176	<.001	<.001	3	20
OESOPHAGUS	Regulation of chromosome condensation →	+0.243	+1.660	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.168	+1.711	<.001	<.001	3	20
OESOPHAGUS	Positive regulation of cell cycle process →	+0.152	+1.787	<.001	<.001	3	20
BLOOD_Myeloma	Mitotic spindle assembly →	+0.122	+1.226	<.001	.002	3	20
OESOPHAGUS	Negative regulation of cell cycle process →	+0.089	+1.498	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,800 associations by consensus.

Protein localization to condensed chromosome by MAD2L1 expression — OESOPHAGUS

Explore this box plot interactively →