MAD1L1

Across TCGA pan-cancer cohorts, MAD1L1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MAD1L1 data layer compared with 31 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MAD1L1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MAD1L1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and OV show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where MAD1L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.296	1.000	.003	48	view →
LSCC	OS	Tertile	All	0.920	0.614	.003	10	view →
PDAC	DFS	Quartile	All	0.571	0.826	.012	8	view →
OV	DFS	Median	All	1.000	0.870	.045	4	view →
CCRCC	OS	Median	All	0.905	0.983	.028	4	view →
LUAD	DFS	Tertile	All	0.711	1.000	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MAD1L1–HNSC (OS)

Open the HNSC breakdown →