MAD1L1

Across TCGA patient cohorts, MAD1L1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,581 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MAD1L1-associated genes across cancer lineages are DNAAF5, CENPI, and EIF3B. Each is linked with MAD1L1 in more than 5 cancer types. Because this analysis shows association rather than direction, both MAD1L1-to-partner and partner-to-MAD1L1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAD1L1 versus DNAAF5 in LUAD, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAD1L1→partner) and Y-score (partner→MAD1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DNAAF5 →	+0.646	+0.141	<.001	<.001	3	6
GBM	CENPI →	+0.734	+0.180	<.001	<.001	3	5
BRCA	EIF3B →	+0.524	+0.196	<.001	<.001	3	5
BRCA	RAD51AP1 →	+0.760	+0.176	.002	.001	3	5
HNSC	NUP155 →	+0.862	+0.203	<.001	<.001	3	5
GBM	KIF14 →	+0.790	+0.149	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,581 associations by consensus.

MAD1L1 vs DNAAF5 — LUAD

Explore this scatter interactively →