MAD1L1

Across TCGA cell cohorts, MAD1L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,354 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MAD1L1-associated GO terms across cancer lineages are Deactivation of mitotic spindle assembly checkpoint, Regulation of metaphase plate congression, and Positive regulation of mitotic sister chromatid segregation. Each is linked with MAD1L1 in more than 19 cancer types. Because this analysis shows association rather than direction, both MAD1L1-to-partner and partner-to-MAD1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Deactivation of mitotic spindle assembly checkpoint grouped by MAD1L1-low versus MAD1L1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAD1L1→partner) and Y-score (partner→MAD1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Deactivation of mitotic spindle assembly checkpoint →	+0.198	+1.886	<.001	<.001	3	20
BREAST	Regulation of metaphase plate congression →	+0.184	+1.200	<.001	<.001	3	16
BREAST	Positive regulation of mitotic sister chromatid segregation →	+0.169	+0.787	<.001	<.001	3	15
CNS	Negative regulation of cell cycle checkpoint →	+0.170	+1.040	<.001	<.001	3	13
CNS	Negative regulation of spindle checkpoint →	+0.174	+1.041	<.001	<.001	3	12
CNS	Negative regulation of mitotic spindle assembly checkpoint signaling →	+0.174	+1.041	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,354 associations by consensus.

Deactivation of mitotic spindle assembly checkpoint by MAD1L1 expression — SKIN

Explore this box plot interactively →