MAD1L1

Across TCGA cell cohorts, MAD1L1 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAD1L1-associated genes across cancer lineages are C1orf189, IRGC, and DAZ4. Each is linked with MAD1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAD1L1-to-partner and partner-to-MAD1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf189 grouped by MAD1L1-low versus MAD1L1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAD1L1→partner) and Y-score (partner→MAD1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C1orf189 →	+0.152	+4.186	.001	.001	3	2
CNS	IRGC →	+0.028	+3.866	.001	.006	3	2
LARGE_INTESTINE	DAZ4 →	+0.109	+2.977	.008	.006	3	2
SOFT_TISSUE	LRRC74A →	+0.014	+4.584	<.001	<.001	3	1
SOFT_TISSUE	FLG2 →	+0.071	+3.714	.004	.004	3	1
SOFT_TISSUE	OR4D6 →	+0.023	+3.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

C1orf189 by MAD1L1 expression — SOFT_TISSUE

Explore this box plot interactively →