MACROD1

Across TCGA pan-cancer cohorts, MACROD1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MACROD1 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MACROD1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MACROD1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where MACROD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.913	0.761	.005	21	view →
CCRCC	OS	Tertile	IV	1.000	0.067	.036	7	view →
PDAC	OS	Quartile	III,IV	0.178	0.583	.039	7	view →
LSCC	DFS	Median	All	0.464	0.907	.009	6	view →
GBM	DFS	Tertile	All	0.756	0.671	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MACROD1–LUAD (OS)

Open the LUAD breakdown →