MACROD1

Across TCGA cell cohorts, MACROD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,655 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MACROD1-associated GO terms across cancer lineages are Peptidyl-glutamate ADP-deribosylation, Protein de-ADP-ribosylation, and Nucleoside metabolic process. Each is linked with MACROD1 in more than 18 cancer types. Because this analysis shows association rather than direction, both MACROD1-to-partner and partner-to-MACROD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-glutamate ADP-deribosylation grouped by MACROD1-low versus MACROD1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MACROD1→partner) and Y-score (partner→MACROD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Peptidyl-glutamate ADP-deribosylation →	+0.301	+2.231	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Protein de-ADP-ribosylation →	+0.229	+1.961	<.001	<.001	3	19
LUNG_SCLC	Nucleoside metabolic process →	+0.111	+0.674	.003	.002	3	9
LUNG_SCLC	Purine nucleoside metabolic process →	+0.164	+0.892	<.001	.001	3	8
LIVER	Positive regulation of translational initiation →	-0.121	-1.092	.002	.002	3	7
BONE	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.168	+1.339	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,655 associations by consensus.

Peptidyl-glutamate ADP-deribosylation by MACROD1 expression — URINARY_TRACT

Explore this box plot interactively →