MACROD1

Across TCGA cell cohorts, MACROD1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MACROD1-associated genes across cancer lineages are SEPTIN14, CPLX4, and ASCL3. Each is linked with MACROD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MACROD1-to-partner and partner-to-MACROD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14 grouped by MACROD1-low versus MACROD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACROD1→partner) and Y-score (partner→MACROD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEPTIN14 →	+0.006	+3.099	.001	.002	3	1
LARGE_INTESTINE	CPLX4 →	+0.019	+3.222	.006	.002	3	1
LARGE_INTESTINE	ASCL3 →	+0.168	+2.989	<.001	.003	3	1
LARGE_INTESTINE	DBX2 →	+0.009	+3.240	<.001	.004	3	1
LARGE_INTESTINE	ACTL7A →	+0.018	+3.145	.005	.004	3	1
LARGE_INTESTINE	SAMD7 →	+0.013	+3.141	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SEPTIN14 by MACROD1 expression — LARGE_INTESTINE

Explore this box plot interactively →