MACORIS

Across TCGA pan-cancer cohorts, MACORIS RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MACORIS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MACORIS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MACORIS is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

KIRC, LUSC, and UCEC are the cancer types where MACORIS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MACORIS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.266	<.001	12	view →
LUSC	All	III,IV	−1.081	<.001	7	view →
UCEC	All	All	−0.957	<.001	6	view →
HNSC	Male	IV	−0.519	<.001	6	view →
BLCA	All	III,IV	−0.430	.008	6	view →
KIRP	All	All	+0.682	<.001	5	view →
LIHC	All	II,III,IV	+0.295	<.001	5	view →
KICH	Male	II,III,IV	−0.511	.005	4	view →
READ	All	III,IV	−0.805	.011	3	view →
COAD	All	All	−0.314	.010	3	view →
LUAD	Female	III,IV	−0.662	.005	2	view →
PRAD	All	All	−0.240	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MACORIS–KIRC

Open the KIRC breakdown →