MACF1

Across TCGA pan-cancer cohorts, MACF1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MACF1 data layer compared with 24 for mass-spec protein and 14 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MACF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MACF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where MACF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.750	0.552	.010	24	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	14	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.333	.005	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MACF1–HNSC (DFS)

Open the HNSC breakdown →