MACF1

Across TCGA patient cohorts, MACF1 mutation is significantly associated with the RNA expression of many other genes, with 9,854 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MACF1-associated genes across cancer lineages are CCNB1, FCER1A, and CDCA2. Each is linked with MACF1 in more than 6 cancer types. Because this analysis shows association rather than direction, both MACF1-to-partner and partner-to-MACF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNB1 grouped by MACF1-low versus MACF1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACF1→partner) and Y-score (partner→MACF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CCNB1 →	+0.657	+2.611	.001	<.001	3	7
LUAD	FCER1A →	-1.263	-2.573	<.001	<.001	3	6
COAD	CDCA2 →	+0.721	+1.839	<.001	<.001	3	6
LUAD	SNRPD3 →	+0.298	+1.689	<.001	.006	3	6
OV	KNSTRN →	+0.507	+2.700	.003	.006	3	6
LUAD	MED8 →	+0.289	+2.087	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,854 associations by consensus.

CCNB1 by MACF1 expression — LUAD

Explore this box plot interactively →