MACF1

Across TCGA patient cohorts, MACF1 mutation is significantly associated with the total protein of many other genes, with 115 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MACF1-associated genes across cancer lineages are Caspase-7-cleavedD198, Caveolin-1, and 4E-BP1. Each is linked with MACF1 in more than 6 cancer types. Because this analysis shows association rather than direction, both MACF1-to-partner and partner-to-MACF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MACF1-low versus MACF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACF1→partner) and Y-score (partner→MACF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.348	+1.503	<.001	<.001	3	7
STAD	Caveolin-1 →	-0.614	-2.000	.005	.002	3	5
STAD	4E-BP1 →	+0.265	+2.000	.002	<.001	3	5
LUAD	Cyclin-B1 →	+0.487	+2.459	.004	.017	3	5
LUAD	Cyclin-E2 →	+0.162	+2.016	<.001	.015	3	5
COAD	eIF4E →	+0.142	+1.847	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

Caspase-7-cleavedD198 by MACF1 expression — COAD

Explore this box plot interactively →