MACF1

Across TCGA cell cohorts, MACF1 mutation is significantly associated with the RNA expression of many other genes, with 3,001 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MACF1-associated genes across cancer lineages are REEP4, PDE12, and ZNF839. Each is linked with MACF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MACF1-to-partner and partner-to-MACF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REEP4 grouped by MACF1-low versus MACF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACF1→partner) and Y-score (partner→MACF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REEP4 →	+0.578	+1.405	<.001	.005	3	5
LARGE_INTESTINE	PDE12 →	+0.430	+1.405	.004	.005	3	5
SOFT_TISSUE	ZNF839 →	+0.900	+3.214	<.001	.006	3	4
LARGE_INTESTINE	MTFMT →	+0.527	+2.584	<.001	.001	3	4
CNS	PGM2 →	+0.619	+2.700	.001	.001	3	4
LARGE_INTESTINE	DESI1 →	+0.430	+1.906	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,001 associations by consensus.

REEP4 by MACF1 expression — LARGE_INTESTINE

Explore this box plot interactively →