Across TCGA pan-cancer cohorts, MACC1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MACC1 data layer compared with 20 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MACC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MACC1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where MACC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	II,III,IV	1.000	0.647	.003	32	view →
PDAC	OS	Tertile	All	0.812	0.929	.022	11	view →
HNSC	OS	Quartile	IV	0.886	0.554	.028	4	view →
LUAD	DFS	Median	All	0.682	0.916	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: MACC1 tumor-vs-normal RNA expression · all MACC1 data types