Across TCGA cell cohorts, MACC1 mutation is significantly associated with the RNA expression of many other genes, with 203 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MACC1-associated genes across cancer lineages are ASCL3, MYH1, and STRA8. Each is linked with MACC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MACC1-to-partner and partner-to-MACC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACC1→partner) and Y-score (partner→MACC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASCL3 →	+0.134	+2.404	.001	.009	3	2
PANCREAS	MYH1 →	+0.029	+5.000	<.001	.006	3	1
PANCREAS	STRA8 →	+0.023	+5.000	<.001	.006	3	1
PANCREAS	DBX2 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	KCNK18 →	+0.019	+5.000	<.001	.006	3	1
PANCREAS	PNLIPRP1 →	+0.049	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 203 associations by consensus.

Exploration

MACC1 survival (RNA) · tumor vs normal (RNA) · all MACC1 data types