MACC1-AS1

Across TCGA pan-cancer cohorts, MACC1-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated MACC1-AS1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher MACC1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MACC1-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and KIRP show a favorable association.

BLCA, ESCA, and DLBC are the cancer types where MACC1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Quartile	II,III,IV	0.567	0.378	.012	40	view →
ESCA	DFS	Tertile	II,III,IV	0.127	0.877	.004	25	view →
DLBC	OS	Tertile	II,III,IV	0.118	0.802	.025	18	view →
THYM	DFS	Tertile	All	0.661	0.911	.020	12	view →
KIRP	DFS	Median	All	0.805	0.502	.001	12	view →
KIRC	OS	Quartile	All	0.777	0.609	.017	9	view →
ACC	DFS	Tertile	IV	0.627	0.260	.036	9	view →
CESC	OS	Median	II,III,IV	0.687	0.378	.028	8	view →
THCA	OS	Quartile	IV	0.865	1.000	.010	7	view →
READ	OS	Median	III,IV	0.767	0.303	.020	4	view →
HNSC	DFS	Tertile	IV	0.721	0.600	.035	4	view →
LUSC	DFS	Quartile	III,IV	0.574	0.264	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

MACC1-AS1–BLCA (OS)

Open the BLCA breakdown →