MAB21L3

Across TCGA cell cohorts, MAB21L3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,808 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MAB21L3-associated GO terms across cancer lineages are Protein destabilization, Small GTPase-mediated signal transduction, and Regulation of synapse structural plasticity. Each is linked with MAB21L3 in more than 6 cancer types. Because this analysis shows association rather than direction, both MAB21L3-to-partner and partner-to-MAB21L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein destabilization grouped by MAB21L3-low versus MAB21L3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAB21L3→partner) and Y-score (partner→MAB21L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein destabilization →	+0.060	+0.454	.002	.006	3	7
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.056	+1.181	<.001	<.001	3	7
URINARY_TRACT	Regulation of synapse structural plasticity →	-1.342	-0.804	<.001	.002	3	7
URINARY_TRACT	Negative regulation of supramolecular fiber organization →	+0.076	+0.726	<.001	<.001	3	7
URINARY_TRACT	Regulation of IRE1-mediated unfolded protein response →	+0.117	+0.959	<.001	.001	3	6
LUNG_NSCLC_LUSC	Mammary gland development →	+0.114	+0.491	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,808 associations by consensus.

Protein destabilization by MAB21L3 expression — LUNG_NSCLC_LUSC

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