MAB21L1

Across TCGA patient cohorts, MAB21L1 mutation is significantly associated with the RNA expression of many other genes, with 5,529 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAB21L1-associated genes across cancer lineages are SPC24, SAP18, and RACGAP1. Each is linked with MAB21L1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAB21L1-to-partner and partner-to-MAB21L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPC24 grouped by MAB21L1-low versus MAB21L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAB21L1→partner) and Y-score (partner→MAB21L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPC24 →	+0.610	+2.321	<.001	<.001	3	4
UCEC	SAP18 →	+0.350	+4.191	<.001	<.001	3	3
UCEC	RACGAP1 →	+0.689	+1.818	<.001	<.001	3	3
UCEC	TK1 →	+0.488	+3.828	.002	<.001	3	3
UCEC	UQCRH →	+0.732	+2.072	.001	<.001	3	3
UCEC	EIF3F →	+0.396	+1.818	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,529 associations by consensus.

SPC24 by MAB21L1 expression — UCEC

Explore this box plot interactively →