MAB21L1

Across TCGA patient cohorts, MAB21L1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAB21L1-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and eIF4E. Each is linked with MAB21L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAB21L1-to-partner and partner-to-MAB21L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MAB21L1-low versus MAB21L1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAB21L1→partner) and Y-score (partner→MAB21L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.404	+3.012	.001	.018	3	3
COAD	Caspase-7-cleavedD198 →	+1.490	+3.008	<.001	.019	3	3
COAD	eIF4E →	+0.312	+3.012	<.001	.018	3	2
COAD	TIGAR →	+0.451	+3.008	.028	.019	2	3
COAD	CD49b →	+0.421	+3.008	.006	.019	3	2
UCEC	JNK2 →	+0.213	+1.512	<.001	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PCNA by MAB21L1 expression — COAD

Explore this box plot interactively →