LZTS1

Across TCGA pan-cancer cohorts, LZTS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LZTS1 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LZTS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LZTS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where LZTS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.613	0.921	<.001	66	view →
UCEC	OS	Median	II,III,IV	1.000	0.606	.014	14	view →
CCRCC	DFS	Quartile	III,IV	0.830	0.441	.015	9	view →
LSCC	DFS	Tertile	II,III,IV	0.330	1.000	.006	8	view →
PDAC	DFS	Median	III,IV	0.463	0.242	.009	7	view →
LUAD	DFS	Median	All	0.670	0.828	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LZTS1–HNSC (DFS)

Open the HNSC breakdown →