LZTS1

Across TCGA patient cohorts, LZTS1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LZTS1-associated genes across cancer lineages are eEF2, INPP4B, and N-Ras. Each is linked with LZTS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LZTS1-to-partner and partner-to-LZTS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by LZTS1-low versus LZTS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTS1→partner) and Y-score (partner→LZTS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.221	+1.807	.049	.024	3	2
COAD	INPP4B →	-0.390	-2.313	.020	.035	3	2
UCEC	N-Ras →	-0.088	-2.295	.018	.033	3	2
UCEC	ATM →	-0.344	-2.102	.016	.016	3	2
UCEC	4E-BP1 →	+0.394	+4.169	<.001	<.001	3	2
COAD	ASNS →	+0.418	+2.330	.019	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eEF2 by LZTS1 expression — UCEC

Explore this box plot interactively →