LZTS1

Across TCGA cell cohorts, LZTS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,247 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LZTS1-associated GO terms across cancer lineages are Regulation of stem cell population maintenance, Negative regulation of chromosome organization, and Regulation of double-strand break repair. Each is linked with LZTS1 in more than 11 cancer types. Because this analysis shows association rather than direction, both LZTS1-to-partner and partner-to-LZTS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of stem cell population maintenance grouped by LZTS1-low versus LZTS1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTS1→partner) and Y-score (partner→LZTS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of stem cell population maintenance →	+0.062	+0.306	.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome organization →	+0.090	+0.342	<.001	.002	3	11
LUNG_SCLC	Regulation of double-strand break repair →	+0.066	+2.360	.001	<.001	2	12
SOFT_TISSUE	Positive regulation of mitotic cell cycle phase transition →	+0.103	+2.049	<.001	<.001	3	10
SOFT_TISSUE	Microtubule cytoskeleton organization involved in mitosis →	+0.106	+2.120	<.001	<.001	3	10
SOFT_TISSUE	Positive regulation of DNA repair →	+0.065	+2.181	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,247 associations by consensus.

Regulation of stem cell population maintenance by LZTS1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →