LZTS1

Across TCGA cell cohorts, LZTS1 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LZTS1-associated genes across cancer lineages are SLC5A1, SLC32A1, and GML. Each is linked with LZTS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LZTS1-to-partner and partner-to-LZTS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A1 grouped by LZTS1-low versus LZTS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTS1→partner) and Y-score (partner→LZTS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC5A1 →	+0.056	+4.291	<.001	<.001	3	1
BLOOD_Leukemia	SLC32A1 →	+0.542	+3.034	<.001	.004	3	1
BLOOD_Leukemia	GML →	+0.049	+3.304	.001	.001	3	1
BLOOD_Leukemia	TNFSF8 →	+1.368	+3.572	.005	.003	3	1
BLOOD_Leukemia	C9 →	+1.281	+3.697	<.001	.002	3	1
BLOOD_Leukemia	SV2C →	+0.317	+3.956	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

SLC5A1 by LZTS1 expression — BLOOD_Leukemia

Explore this box plot interactively →