LZTS1

Across TCGA cell cohorts, LZTS1 mutation is significantly associated with the mutation status of many other genes, with 4,151 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LZTS1-associated genes across cancer lineages are PCDHA3, STAG2, and TANGO6. Each is linked with LZTS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LZTS1-to-partner and partner-to-LZTS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDHA3 grouped by LZTS1-low versus LZTS1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTS1→partner) and Y-score (partner→LZTS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PCDHA3 →	+4.014	+4.969	.008	.008	1	4
BLOOD_Leukemia	STAG2 →	+3.012	+3.209	<.001	<.001	1	4
LARGE_INTESTINE	TANGO6 →	+2.289	+3.182	.008	.008	1	4
SKIN	ADGB →	+3.053	+3.718	.006	.006	1	4
LARGE_INTESTINE	ZNF835 →	+2.459	+4.247	.001	.001	1	4
OVARY	HNF1A →	+5.415	+5.415	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,151 associations by consensus.

PCDHA3 by LZTS1 expression — BLOOD_Lymphoma

Explore this box plot interactively →