LZTR1

Across TCGA patient cohorts, LZTR1 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LZTR1-associated genes across cancer lineages are eEF2, mTOR_pS2448, and 4E-BP1. Each is linked with LZTR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LZTR1-to-partner and partner-to-LZTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by LZTR1-low versus LZTR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTR1→partner) and Y-score (partner→LZTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.372	+1.637	<.001	.001	3	3
UCEC	mTOR_pS2448 →	-0.117	-1.752	.007	.011	3	3
COAD	4E-BP1 →	+0.266	+2.467	.005	.011	3	3
COAD	PCNA →	+0.392	+3.593	<.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.265	-2.459	<.001	<.001	3	2
UCEC	A-Raf_pS299 →	-0.178	-2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

eEF2 by LZTR1 expression — UCEC

Explore this box plot interactively →