LZTR1

Across TCGA cell cohorts, LZTR1 mutation is significantly associated with the RNA expression of many other genes, with 766 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LZTR1-associated genes across cancer lineages are NTN5, SNAP91, and KSR2. Each is linked with LZTR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LZTR1-to-partner and partner-to-LZTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NTN5 grouped by LZTR1-low versus LZTR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTR1→partner) and Y-score (partner→LZTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NTN5 →	+0.319	+3.234	.003	.005	3	3
BLOOD_Lymphoma	SNAP91 →	+0.212	+3.459	.005	.009	3	2
BLOOD_Leukemia	KSR2 →	+0.368	+3.762	<.001	.001	3	2
BLOOD_Leukemia	NKX2-6 →	+0.242	+3.464	<.001	.003	3	2
BLOOD_Leukemia	SLC6A17 →	+0.137	+3.622	<.001	<.001	3	2
LARGE_INTESTINE	CDKN1B →	+0.718	+3.743	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 766 associations by consensus.

NTN5 by LZTR1 expression — LARGE_INTESTINE

Explore this box plot interactively →