LZTFL1

Across TCGA pan-cancer cohorts, LZTFL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LZTFL1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LZTFL1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LZTFL1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where LZTFL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.607	0.815	.003	50	view →
CCRCC	DFS	Median	All	0.597	0.879	.002	22	view →
PDAC	DFS	Tertile	IV	0.934	0.235	.024	9	view →
UCEC	DFS	Quartile	All	1.000	0.829	.008	8	view →
COAD	DFS	Median	III,IV	1.000	0.898	.043	6	view →
LSCC	DFS	Median	II,III,IV	0.834	1.000	.004	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LZTFL1–HNSC (OS)

Open the HNSC breakdown →