LZTFL1

Across TCGA patient cohorts, LZTFL1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LZTFL1-associated genes across cancer lineages are ASNS, EGFR_pY1068, and FoxM1. Each is linked with LZTFL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LZTFL1-to-partner and partner-to-LZTFL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by LZTFL1-low versus LZTFL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTFL1→partner) and Y-score (partner→LZTFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.482	+3.169	.004	.019	3	2
UCEC	EGFR_pY1068 →	-0.230	-2.584	.049	.011	3	1
UCEC	FoxM1 →	+0.287	+2.817	.017	.036	2	2
UCEC	GATA6 →	-0.157	-3.000	.043	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.154	-3.000	.049	.036	3	1
UCEC	Ku80 →	+0.221	+1.887	.044	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ASNS by LZTFL1 expression — UCEC

Explore this box plot interactively →