LYZL4

Across TCGA patient cohorts, LYZL4 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYZL4-associated genes across cancer lineages are RNA5SP412, SMIM11P1, and HSBP1P2. Each is linked with LYZL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYZL4-to-partner and partner-to-LYZL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by LYZL4-low versus LYZL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYZL4→partner) and Y-score (partner→LYZL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+1.459	+3.289	<.001	.001	3	2
SKCM	SMIM11P1 →	+0.246	+4.979	<.001	.009	3	2
UCEC	HSBP1P2 →	+0.739	+3.373	<.001	.008	3	1
LUSC	KRTAP9-11P →	+0.134	+7.924	<.001	.008	3	1
LUAD	RN7SL196P →	+0.204	+7.930	<.001	.008	3	1
SKCM	RNU6-1169P →	+0.365	+5.362	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

RNA5SP412 by LYZL4 expression — UCEC

Explore this box plot interactively →