LYZL4

Across TCGA patient cohorts, LYZL4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYZL4-associated genes across cancer lineages are MYH11, Tuberin_pT1462, and Mre11. Each is linked with LYZL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYZL4-to-partner and partner-to-LYZL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by LYZL4-low versus LYZL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYZL4→partner) and Y-score (partner→LYZL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYH11 →	+1.527	+3.000	.021	.037	3	1
UCEC	Tuberin_pT1462 →	+0.396	+2.817	.003	.036	3	1
UCEC	Mre11 →	-0.142	-3.000	.004	.037	2	1
UCEC	ACC_pS79 →	+0.479	+3.000	.016	.037	1	1
UCEC	MEK1 →	+0.505	+3.000	.016	.037	1	1
UCEC	N-Ras →	-0.166	-2.986	.015	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MYH11 by LYZL4 expression — UCEC

Explore this box plot interactively →