LYZL2

Across TCGA patient cohorts, LYZL2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYZL2-associated genes across cancer lineages are Gab2, JNK2, and Notch1. Each is linked with LYZL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYZL2-to-partner and partner-to-LYZL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by LYZL2-low versus LYZL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYZL2→partner) and Y-score (partner→LYZL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.524	+3.000	.011	.037	3	1
UCEC	JNK2 →	+0.333	+2.834	.003	.034	3	1
UCEC	Notch1 →	+0.209	+3.000	.010	.037	3	1
UCEC	ATM →	-0.838	-3.000	.001	.037	2	1
UCEC	Caspase-8 →	-0.302	-3.000	.038	.037	2	1
UCEC	p21 →	+0.234	+3.000	.035	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Gab2 by LYZL2 expression — UCEC

Explore this box plot interactively →