LYZL2

Across TCGA cell cohorts, LYZL2 mutation is significantly associated with the mutation status of many other genes, with 845 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LYZL2-associated genes across cancer lineages are SLC25A6, SNW1, and CARM1. Each is linked with LYZL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYZL2-to-partner and partner-to-LYZL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A6 grouped by LYZL2-low versus LYZL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYZL2→partner) and Y-score (partner→LYZL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC25A6 →	+3.087	+4.392	.005	.005	1	2
LARGE_INTESTINE	SNW1 →	+5.672	+5.672	<.001	<.001	1	2
LARGE_INTESTINE	CARM1 →	+2.865	+4.217	.007	.007	1	2
LARGE_INTESTINE	DDHD2 →	+3.672	+4.799	.002	.002	1	1
LARGE_INTESTINE	CHERP →	+2.865	+4.217	.007	.007	1	1
LARGE_INTESTINE	B4GALT1 →	+4.672	+5.329	<.001	<.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 845 associations by consensus.

SLC25A6 by LYZL2 expression — LARGE_INTESTINE

Explore this box plot interactively →