LYZL1

Across TCGA patient cohorts, LYZL1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYZL1-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with LYZL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYZL1-to-partner and partner-to-LYZL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by LYZL1-low versus LYZL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYZL1→partner) and Y-score (partner→LYZL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.107	-2.973	.028	.035	3	1
UCEC	EGFR_pY1068 →	-0.374	-3.584	.001	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.271	-3.321	<.001	.010	3	1
UCEC	MEK1 →	+0.471	+3.459	.007	.005	3	1
UCEC	N-Ras →	-0.143	-2.446	.012	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.516	-3.000	.017	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

14-3-3_beta by LYZL1 expression — UCEC

Explore this box plot interactively →