LYZ

Across TCGA cell cohorts, LYZ RNA expression is significantly associated with the go_rna of many other GO terms, with 4,640 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LYZ-associated GO terms across cancer lineages are Neutrophil-mediated killing of fungus, Response to transition metal nanoparticle, and Keratinization. Each is linked with LYZ in more than 8 cancer types. Because this analysis shows association rather than direction, both LYZ-to-partner and partner-to-LYZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophil-mediated killing of fungus grouped by LYZ-low versus LYZ-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LYZ→partner) and Y-score (partner→LYZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Neutrophil-mediated killing of fungus →	+1.164	+4.287	<.001	<.001	3	9
CNS	Response to transition metal nanoparticle →	-0.173	-0.810	<.001	.001	3	7
BONE	Keratinization →	-0.380	-0.469	<.001	.001	3	7
STOMACH	Regulation of Ras protein signal transduction →	+0.094	+6.623	.006	.001	3	7
UPPER_AERODIGESTIVE_TRACT	Oocyte growth →	+0.171	+0.653	<.001	.002	3	6
LARGE_INTESTINE	Metanephric tubule morphogenesis →	+0.232	+3.930	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,640 associations by consensus.

Neutrophil-mediated killing of fungus by LYZ expression — BLOOD_Leukemia

Explore this box plot interactively →