LYVE1

Across TCGA patient cohorts, LYVE1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYVE1-associated genes across cancer lineages are FOXO3a_pS318_S321, GSK-3_pS9, and GSK-3a-b_pS21_S9. Each is linked with LYVE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYVE1-to-partner and partner-to-LYVE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by LYVE1-low versus LYVE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYVE1→partner) and Y-score (partner→LYVE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.199	-2.999	.002	.035	3	1
UCEC	GSK-3_pS9 →	-0.676	-3.169	.001	.019	3	1
UCEC	GSK-3a-b_pS21_S9 →	-0.559	-2.999	.012	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.242	-3.308	.006	.010	3	1
UCEC	Ku80 →	+0.285	+2.183	.021	.035	3	1
UCEC	Notch1 →	+0.232	+3.321	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

FOXO3a_pS318_S321 by LYVE1 expression — UCEC

Explore this box plot interactively →