LYST

Across TCGA patient cohorts, LYST protein abundance is significantly associated with the RNA expression of many other genes, with 13,915 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LYST-associated genes across cancer lineages are KCND3, LYST-AS1, and MAOB. Each is linked with LYST in more than 4 cancer types. Because this analysis shows association rather than direction, both LYST-to-partner and partner-to-LYST results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LYST versus KCND3 in BRCA, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYST→partner) and Y-score (partner→LYST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KCND3 →	+0.963	+0.170	<.001	.002	3	5
UCEC	LYST-AS1 →	+0.960	+0.370	<.001	<.001	3	5
UCEC	MAOB →	+1.499	+0.324	<.001	<.001	3	5
BRCA	NAV3 →	+0.958	+0.263	.001	.001	3	5
UCEC	CCNE1 →	-1.571	-0.437	<.001	<.001	3	4
LSCC	FOXM1 →	-0.727	-0.199	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,915 associations by consensus.

LYST vs KCND3 — BRCA

Explore this scatter interactively →