LYST

Across TCGA patient cohorts, LYST mutation is significantly associated with the total protein of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYST-associated genes across cancer lineages are Src_pY527, Notch1, and ASNS. Each is linked with LYST in more than 4 cancer types. Because this analysis shows association rather than direction, both LYST-to-partner and partner-to-LYST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by LYST-low versus LYST-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYST→partner) and Y-score (partner→LYST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Src_pY527 →	-0.439	-1.584	.006	.017	3	5
UCEC	Notch1 →	+0.135	+1.378	<.001	<.001	3	4
UCEC	ASNS →	+0.293	+1.415	.001	.007	3	4
LUAD	IGFBP2 →	-0.602	-2.000	.023	.027	3	3
LUAD	Rictor_pT1135 →	-0.127	-2.000	.008	.009	3	3
LUAD	Cyclin-E1 →	+0.228	+1.874	.017	.049	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

Src_pY527 by LYST expression — STAD

Explore this box plot interactively →