LYSMD4

Across TCGA patient cohorts, LYSMD4 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYSMD4-associated genes across cancer lineages are Cyclin-B1, EGFR_pY1173, and 14-3-3_epsilon. Each is linked with LYSMD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYSMD4-to-partner and partner-to-LYSMD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by LYSMD4-low versus LYSMD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYSMD4→partner) and Y-score (partner→LYSMD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.605	+3.584	.025	.002	3	2
UCEC	EGFR_pY1173 →	+0.109	+3.020	.004	.019	3	1
UCEC	14-3-3_epsilon →	+0.101	+3.026	.035	.018	3	1
UCEC	VHL →	-1.086	-2.321	<.001	.034	3	1
UCEC	4E-BP1_pT37_T46 →	-0.512	-2.986	.004	.035	3	1
UCEC	C-Raf →	+0.174	+3.169	.012	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Cyclin-B1 by LYSMD4 expression — UCEC

Explore this box plot interactively →