LYSMD3

Across TCGA patient cohorts, LYSMD3 mutation is significantly associated with the RNA expression of many other genes, with 4,264 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYSMD3-associated genes across cancer lineages are RNU6-340P, MIR3661, and MIR6853. Each is linked with LYSMD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYSMD3-to-partner and partner-to-LYSMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-340P grouped by LYSMD3-low versus LYSMD3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYSMD3→partner) and Y-score (partner→LYSMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-340P →	+0.363	+7.741	<.001	.009	3	2
UCEC	MIR3661 →	+0.603	+1.604	<.001	.006	3	2
BRCA	MIR6853 →	+0.242	+8.057	<.001	.005	3	1
UCEC	TAF15 →	+0.371	+1.936	.009	.003	3	1
UCEC	YTHDF3-AS1 →	+0.739	+2.147	<.001	.009	3	1
UCEC	SNRPGP17 →	+0.190	+1.638	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,264 associations by consensus.

RNU6-340P by LYSMD3 expression — COAD

Explore this box plot interactively →