LYSMD3

Across TCGA cell cohorts, LYSMD3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LYSMD3-associated genes across cancer lineages are WFDC6, OR8B4, and USP17L11. Each is linked with LYSMD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYSMD3-to-partner and partner-to-LYSMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC6 grouped by LYSMD3-low versus LYSMD3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYSMD3→partner) and Y-score (partner→LYSMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WFDC6 →	+0.050	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.027	+4.887	<.001	.009	3	1
BLOOD_Lymphoma	USP17L11 →	+0.042	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	USP17L22 →	+0.026	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

WFDC6 by LYSMD3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →