Across TCGA patient cohorts, LYRM4 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYRM4-associated genes across cancer lineages are JNK_pT183_Y185, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with LYRM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYRM4-to-partner and partner-to-LYRM4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYRM4→partner) and Y-score (partner→LYRM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.192	-2.986	.049	.037	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.585	-2.986	.024	.037	3	1
UCEC	PDCD4 →	-0.805	-2.990	.003	.036	3	1
UCEC	PKC-a_pS657 →	-0.603	-2.990	.006	.036	3	1
UCEC	PKC-a →	-0.555	-3.000	.017	.037	3	1
UCEC	STAT3_pY705 →	-0.426	-2.990	.004	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

LYRM4 survival (RNA) · tumor vs normal (RNA) · all LYRM4 data types