LYRM1

Across TCGA patient cohorts, LYRM1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYRM1-associated genes across cancer lineages are RNU6-169P, DEFB130A, and MIR548X. Each is linked with LYRM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYRM1-to-partner and partner-to-LYRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-169P grouped by LYRM1-low versus LYRM1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYRM1→partner) and Y-score (partner→LYRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-169P →	+0.273	+7.954	<.001	.008	3	1
HNSC	DEFB130A →	+0.124	+7.954	<.001	.008	3	1
HNSC	MIR548X →	+0.337	+7.954	<.001	.008	3	1
HNSC	MIR4445 →	+0.358	+7.954	<.001	.008	3	1
UCEC	AKR1B1P7 →	+0.214	+3.650	.006	.008	3	1
UCEC	MIR98 →	+0.637	+3.386	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

RNU6-169P by LYRM1 expression — HNSC

Explore this box plot interactively →