LYPLAL1

Across TCGA patient cohorts, LYPLAL1 mutation is significantly associated with the RNA expression of many other genes, with 103 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYPLAL1-associated genes across cancer lineages are RNA5SP172, RN7SL788P, and EIF3JP1. Each is linked with LYPLAL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LYPLAL1-to-partner and partner-to-LYPLAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP172 grouped by LYPLAL1-low versus LYPLAL1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPLAL1→partner) and Y-score (partner→LYPLAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP172 →	+0.471	+5.015	<.001	.009	3	3
SKCM	RN7SL788P →	+0.163	+5.034	<.001	.002	3	2
UCEC	EIF3JP1 →	+0.299	+2.842	<.001	.002	3	2
UCEC	RN7SL134P →	+0.193	+3.336	<.001	<.001	3	2
HNSC	RNA5SP191 →	+0.724	+6.936	<.001	<.001	3	1
HNSC	RNA5SP238 →	+0.345	+5.736	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

RNA5SP172 by LYPLAL1 expression — HNSC

Explore this box plot interactively →