LYPLAL1

Across TCGA cell cohorts, LYPLAL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,947 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LYPLAL1-associated GO terms across cancer lineages are Establishment of protein localization to endoplasmic reticulum membrane, Vesicle targeting, rough ER to cis-Golgi, and COPII vesicle coating. Each is linked with LYPLAL1 in more than 12 cancer types. Because this analysis shows association rather than direction, both LYPLAL1-to-partner and partner-to-LYPLAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to endoplasmic reticulum membrane grouped by LYPLAL1-low versus LYPLAL1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPLAL1→partner) and Y-score (partner→LYPLAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Establishment of protein localization to endoplasmic reticulum membrane →	+0.150	+1.382	<.001	.001	3	13
CNS	Vesicle targeting, rough ER to cis-Golgi →	+0.065	+0.527	<.001	<.001	3	9
URINARY_TRACT	COPII vesicle coating →	+0.105	+0.819	.003	.003	3	9
CNS	Geranyl diphosphate metabolic process →	+0.088	+0.625	<.001	<.001	2	9
OESOPHAGUS	Negative regulation of Golgi to plasma membrane protein transport →	+0.183	+0.849	.001	.004	3	8
LUNG_NSCLC_LUAD	Negative regulation of protein localization to plasma membrane →	+0.091	+0.641	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,947 associations by consensus.

Establishment of protein localization to endoplasmic reticulum membrane by LYPLAL1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →