LYPLA2

Across TCGA patient cohorts, LYPLA2 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYPLA2-associated genes across cancer lineages are Class-switched memory B-cells, mv Endothelial cells, and CD4+ T-cells. Each is linked with LYPLA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYPLA2-to-partner and partner-to-LYPLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Class-switched memory B-cells grouped by LYPLA2-low versus LYPLA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPLA2→partner) and Y-score (partner→LYPLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Class-switched memory B-cells →	-0.052	-2.807	.037	.003	3	1
UCEC	mv Endothelial cells →	-0.022	-2.104	.030	.019	3	1
SKCM	CD4+ T-cells →	+0.015	+5.328	.035	.048	3	1
UCEC	Endothelial cells →	-0.036	-2.764	.030	.003	2	1
UCEC	lymphatic Endothelial cells →	-0.023	-2.061	.024	.019	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Class-switched memory B-cells by LYPLA2 expression — UCEC

Explore this box plot interactively →