LYPLA2

Across TCGA cell cohorts, LYPLA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,053 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LYPLA2-associated GO terms across cancer lineages are Cellular response to methionine, Response to methionine, and Negative regulation of protein localization to chromatin. Each is linked with LYPLA2 in more than 9 cancer types. Because this analysis shows association rather than direction, both LYPLA2-to-partner and partner-to-LYPLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to methionine grouped by LYPLA2-low versus LYPLA2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPLA2→partner) and Y-score (partner→LYPLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Cellular response to methionine →	+0.100	+0.637	.004	.003	3	10
LIVER	Response to methionine →	+0.100	+0.637	.004	.003	3	10
LUNG_NSCLC_LUAD	Negative regulation of protein localization to chromatin →	+0.116	+0.682	<.001	<.001	3	9
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.139	+0.625	.002	.003	3	9
BLOOD_Lymphoma	Negative regulation of mRNA splicing, via spliceosome →	+0.077	+0.646	<.001	<.001	3	9
BLOOD_Lymphoma	Cytosolic transport →	+0.048	+0.747	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,053 associations by consensus.

Cellular response to methionine by LYPLA2 expression — LIVER

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